Synthesis, characterization of diorganotin(IV) complexes of <i>N</i>‐(2‐hydroxyarylidene)amino‐acetic acid and antitumour screening <i>in vivo</i> in Ehrlich ascites carcinoma cells

Abstract

Abstract Some new diorganotin(IV) complexes have­been prepared by reacting potassium N ‐(2‐hydroxyarylidene)aminoacetate with R 2 SnCl 2 (R =­Me, n Bu,Ph). The complexes have been characterized by 1 H, 13 C, 119 Sn NMR, IR and 119m Sn Mössbauer spectroscopic techniques in combination with elemental analysis. In the solid state, the complexes possess penta‐ and hexa‐coordinated tin centres. The hexa‐coordinated tin complexes were found to dissociate in solution, giving rise to penta‐coordinated species­as revealed by 119 Sn NMR spectroscopy. Antitumour screening in vivo of the complexes L 4 SnPh 2 ,L 4 SnPh 2 ·Ph 3 SnCl and L 4 Sn t Bu 2 · t Bu 2 SnCl 2 (L 4 = N ‐(2‐hydroxyacetophenone)aminoacetate) is also reported. Copyright © 2001 John Wiley &amp; Sons, Ltd.