The Lipid Modifications of Ras that Sense Membrane Environments and Induce Local Enrichment

Abstract

Matching the membrane: The lipid modification of human N-Ras proteins can adapt remarkably to the host membrane by varying its length between 8.7 Å and 15.5 Å, as can be seen in the 2H NMR spectra of deuterated derivatives (see picture). In raft-forming biological membranes, Ras is found in the liquid disordered phase as well as in the phase boundary between liquid-crystalline and raft domains. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.