A New Orally Active Quaternary Ammonium, Ganglion Blocking Drug Capable of Reducing Blood Pressure, SU-3088

Abstract

Experiments were performed in animals to evaluate 4,5,6,7-tetrachloro-2-(2 dimethylaminoethyl)-isoindoline dimethochloride, (Su-3088), as an orally effective ganglion blocking drug. These demonstrated reduction of blood pressure, suppression of vasopressor reflexes and potentiation of the pressor action of epinephrine. Neostigmine deblocked drug effects and returned responses toward normal. Experiments in patients produced reduction of blood pressure, warming of extremities and delay of gastric emptying. Preliminary trial as a treatment for hypertension suggested that the drug may be useful. It has a long period of action, 12 hours or more and a small dose requirement, 50 to 100 mg.