The Reaction of Bone to Tumor Growth From Human Breast Cancer Cells in a Rat Spine Single Metastasis Model

Abstract

A spine single metastasis model was developed by injection of human breast cancer cells into the VB of athymic rats. This is the first report of quantitative evaluation with micro-PET in a spine metastasis model. In addition, the detection of osteogenesis after the introduction of MDA-MB-231 cells in vivo is a novel observation.