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Clozapine in Treatment-Resistant Patients With Schizophrenia, Schizoaffective Disorder, or Psychotic Bipolar Disorder

DOI

109

Citations

0

References

2003

Year

Antonio Ciapparelli, Liliana Dell’Osso, Adolfo Bandettini di Poggio, Claudia Carmassi, Donatella Cecconi, Melania Fenzi, Maria C. Chiavacci, Matteo Bottai, C Ramacciotti, Giovanni Battista Cassano
The Journal of Clinical Psychiatry

Abstract

The findings of this study confirm the efficacy and safety of clozapine for treatment-resistant patients with a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder with psychotic features. Patients with schizoaffective disorder and those with bipolar disorder show greater clinical improvement than those with schizophrenia. Patients with bipolar disorder have the shortest time to response and the highest psychosocial and occupational functioning levels. Patients with schizoaffective disorder have the lowest treatment discontinuation rate.