Synthesis of some new pyrazole‐containing chelating agents

Abstract

Abstract Procedures are described involving the condensation of l‐(hydroxymethyl)pyrazole (1a) and l‐(hydroxymethyl)‐3,5‐dimethylpyrazole (1b) with the following amines (products given in parentheses): ethylamine (2a and 2b), aniline (3a and 3b), N,N′‐dimethyl‐ l,2‐ethanediamine (4a and 4b), 1,2‐ethanediamine (6a and 6b), diethylenetriamine (7a and 7b), triethylenetetramine (8a and 8b) and ammonia (9a and 9b). All amine hydrogens are completely substituted by pyrazol‐1‐ylmethyl groups (compounds 2a‐9a) or (3,5‐dimethylpyrazol‐1‐yl)methyl groups (compounds 2b‐9b with yields being better than 90%.