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Nerve Conduction Studies during the Relative Refractory Period in Sural Nerves of Patients with Uremia
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1974
Year
Electrolyte DisorderPeripheral Nerve InjuryNeuromodulation TherapiesPeripheral NervePeripheral NervesPaired StimuliPeripheral Nervous SystemSocial SciencesMotor InnervationElectrophysiological EvaluationNeurologyMotor NeurophysiologyNeurorehabilitationNeuropathologySensationNerve Conduction StudiesNeuromodulation (Medicine)Relative Refractory PeriodNeurological MonitoringNeurostimulationNervous SystemNeurological AssessmentUrologyNeurophysiologyNeuroanatomySural NervesPhysiologyElectromyographyElectrophysiologyBrain ElectrophysiologyCentral Nervous SystemMedicineAnesthesiology
Sural nerves of 7 uremic patients were investigated electroneurographically and with paired stimuli. The patients had no clinical manifest polyneuropathy and on electromyography no abnormalities of motor innervation. As compared with 15 healthy control persons, conduction velocity was slightly decreased in the patient group (54.9–47.1 m/sec, p<0.01). Application of paired stimuli showed a significant (p<0.01) reduction of the amplitude of the test response in patients already at 3.0-msec stimulus interval and conduction block in 3 of 7 nerves at 1.0-msec stimulus interval. In controls, the test response was still conducted at intervals below 0.8 msec. In contrast to the controls, the latencies of the test responses in the patients were significantly prolonged already at stimulus intervals of 3 and 5 msec.