Endocrinology · 1947 · 25 citations · 0 references
Life SciencesEndocrinologyPhysiologyDiabetologyHormone BiochemistryNeuroendocrinologyDiabetes MellitusGrowth HormoneMammalian EndocrinologyPancreatic HormonesPituitary Gland FunctionPituitary HormonesAnterior Pituitary Hormone SecretionEndocrine Pancreatic FunctionInsulin PhysiologyPancreatic Hormone SecretionPituitary Control Of MetabolismPituitary DysfunctionPituitary Hormone FunctionPituitary Physiology
THE DIABETES which is produced by the administration of anterior pituitary extract (APE) is the result of an interplay of several factors. These include the direct effect of APE upon 1) the pancreas, 2) other endocrine glands, especially the adrenal and thyroid, and 3) other tissues such as muscle and liver. The interaction of these various factors and their impact on the entire organism make the problem of pituitary diabetes exceedingly complex. An understanding of the separate factors is necessary before the problem as a whole can be analyzed. This paper deals with an attempt to study an isolated factor, namely the direct effect of APE upon the insulin-producing cells of the pancreas.