Journal of Analytical Toxicology · 1989 · 16 citations · 0 references
PharmacyPharmacologyToxicologyAnalytical ToxicologyDrug MetabolismMass Spectrometric AnalysisControlled Substance AnalysisDrug DispositionMetabolite IdentificationMonoamine NeurochemistryStimulant ToxicologyToxicological Drug ScreeningBiological MonitoringDrug Metabolite MonitoringGas Chromatography-mass SpectrometryIllicit Drug DetectionMass Spectrometric Drug AnalysisToxicological Analysis Of UrineUrine Drug ScreeningUrine Toxicology Monitoring
A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method has been developed for the simultaneous analysis of methampthetamine and its metabolites (amphetamine, p-hydroxymethamphetamine, and p-hydroxyamphetamine) in monkey urine. The method has been applied to the analysis of urine samples from monkeys singly and repeatedly treated with methamphetamine. We have shown that the repeated administration of methamphetamine causes the reduction of urinary excretion of aromatic hydroxylated metabolites. We propose that the method described here can be used for biological monitoring.