Digestion · 2009 · 38 citations · 0 references
MedicinePharmacologyPhysiologyHemodynamic ManagementHepatic PharmacokineticsHepatic PharmacotherapyCirrhosisHemodynamicsHepatic PathophysiologyLiver Blood FlowPortal HypertensionVasopressor TherapyHepatic Vascular ResistanceLiver Vascular ResistancePortal HemodynamicsPortal Hypertension HemodynamicsPortal Venous PressureSplanchnic CirculationSplanchnic VasculatureVascular Resistance
In four cirrhotic patients with portal hypertension we have measured some hemodynamic parameters over 60-120 min; portal venous pressure, hepatic venous pressure, mean arterial blood pressure, hepatic blood flow, transsinusoidal vascular resistance and splanchnic oxygen uptake under treatment with Vasopressin (1 IU/min for 10 min) and glypressin (50 mug/kg body weight). The effect on the parameters was less pronounced with glypressin but of longer duration.