The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

R. H. Purdy, A. Leslie Morrow, Perry H. Moore et al. · Proceedings of the National Academy of Sciences · 1991 · 960 citations

Life Sciences, Neurobiology, Neuroscience +14

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

Veska Uzunova, Yvette I. Sheline, J. M. Davis et al. · Proceedings of the National Academy of Sciences · 1998 · 672 citations

Medicine, Neuroscience, Pharmacology +17

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Fong‐Sen Wu, Terrell T. Gibbs, David H. Farb · Molecular Pharmacology · 1991 · 530 citations

Life Sciences, Neurobiology, Neuroscience +17

Effects of Antidepressant Treatment on Neuroactive Steroids in Major Depression

Elena Romeo, Andreas Ströhle, Gianfranco Spalletta et al. · American Journal of Psychiatry · 1998 · 460 citations

Medicine, Pharmacology, Psychiatry +17

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

Maria Dorota Majewska, Serdar Demirgo ̈ren, Charles E. Spivak et al. · Brain Research · 1990 · 434 citations

Life Sciences, Neuroscience, Pharmacology +16