Publication | Open Access
The Synthesis of Two Phenacetin Metabolites
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Citations
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References
1972
Year
Bioorganic ChemistryBiochemistryMedicineNatural SciencesPhenacetin MetabolitesSecondary MetaboliteNew MetaboliteDrug DevelopmentPharmacologyPharmaceutical ChemistrySynthetic ChemistryDrug DiscoveryNatural Product Synthesis
A new metabolite of phenacetin was identified as 4-hydroxy-3-methylthioacetanilide (11). The synthesis of 11 and the isomeric 4-hydroxy-2-methylthioacetanilide (4) as well as that of the previously reported phenacetin metabolite 3-[(5-acetamido-2-hydroxyphenyl)thio]alanine (18) is described.
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