Detection of Human Papillomavirus DNA and p53 Gene Mutations in Esophageal Cancer Samples and Adjacent Normal Mucosa

Abstract

Our results are in favor of the involvement of both aberrant p53 expression and HPV infection in the development of esophageal tumors. The high HPV infection rate in patients from a high-risk region suggests that subjects harboring HPVs (in particular HPV 16) in the esophagus should be considered at risk of esophageal malignancies.