Circulation · 1963 · 47 citations · 0 references
Life SciencesCardiologyPhysiologyCardiac TransplantationElectrophysiologyNeurophysiologyAutonomic Nervous SystemAutonomic Nervous System FunctionAutonomic Nervous System ResponsesHeart TransplantationNeurotransmissionAdrenergic TransmissionAutonomic MechanismsAutonomic NeurotransmissionAutonomic Regulation Of The HeartCardiac Autonomic RegulationCardiovascular Autonomic ControlSympathetic ActivationSympathetic Nervous System Responses
Orthotopic autotransplantation of the canine heart is followed by loss of direct sympathetic and parasympathetic neural regulation. Stimulation of the vagus nerve or stellate ganglion fails to alter cardiac rate. Myocardial catecholamines are depleted and [see figure in the PDF file] hypersensitivity to exogenous l -norepinephrine is present for months. One year after the operation, there is evidence of cardiac reinnervation and return of normal responses to catecholamines.