Immunosuppressive Properties of Monoclonal Antibodies and Human Polyclonal Alloantibodies to the R80K Protein of Trophoblast

Abstract

Those IgG antibodies eluted from microvesicles which bound to K562, and one of the three monoclonals, BA11, inhibited NK killing. The antibodies react with the murine molecule, and BA11 inhibited abortion in all three mouse abortion models. This reinforces the thesis that interference with NK killing can influence abortion/resorption in mice, and the BA11 antibody may effect similar results in analogous human situations.