Gold-Catalyzed Cascade Friedel−Crafts/Furan−Alkyne Cycloisomerizations for the Highly Efficient Synthesis of Arylated (<i>Z</i>)-Enones or -Enals

Abstract

An efficient domino approach for the synthesis of arylated (Z)-enones or -enals through gold(I)-catalyzed reactions of enynols with furans was developed. PPh(3)AuNTf(2) was found to be an excellent catalyst to catalyze both of the Friedel-Crafts and furan/alkyne cyclization reactions in the same vessel. This method offers several advantages such as high stereoselectivities, mild reaction conditions, and easily accessible starting materials.