Metabolite abnormalities in progressive rnultifocal leukoencephalopathy by proton magnetic resonance spectroscopy

Abstract

These MRS findings are consistent with neuropathologic observations of neuronal loss, cell membrane and myelin breakdown, and increased glial activity in PML lesions. The CONTRA abnormalities may be due to remote effects of PML or direct HIV-1 infection. 1H MRS may be useful for characterization and follow-up evaluation of PML lesions.