Metallation studies with pyrimidines

Abstract

2-Alkylamino-4,6-diphenylpyrimidines are acylated only at nitrogen after treatment with lithium di-isopropylamide (LDA). 4,6-Diaryl-1 -benzylpyrimidin-2(1H)-ones can be acylated and alkylated at the α-CH2 group. 1-Methyl-4,6-di-p-tolylpyrimidin-2(1H)-one forms a carbanion which undergoes dimerisation.