Concepedia

The signal transduction cascade regulating the expression of the gap junction protein connexin43 by β‐adrenoceptors

A. Salameh, Silke Krautblatter, Sebastian Karl, Katja Blanke, D Rojas Gomez, Stefan Dhein, D. Pfeiffer, Jan Janoušek

British Journal of Pharmacology · 2009 · 69 citations · 37 references

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Abstract

Beta-adrenoceptor stimulation up-regulated cardiac Cx43 expression via a protein kinase A and MAPK-regulated pathway, possibly involving AP1 and CREB. Cardiomyopathy altered Cx43 expression and distribution.

References

37

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

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Rapid Turnover of Connexin43 in the Adult Rat Heart

Michael A. Beardslee, James G. Laing, Eric C. Beyer et al. · Circulation Research · 1998 · 433 citations · Full text

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

K. C. Goh · The EMBO Journal · 1999 · 376 citations · Full text

, , +12

Regulation of Connexin-43 Gap Junctional Intercellular Communication by Mitogen-activated Protein Kinase

Bonnie J. Warn‐Cramer, G. Trevor Cottrell, Janis M. Burt et al. · Journal of Biological Chemistry · 1998 · 334 citations · Full text

Altered Connexin Expression in Human Congestive Heart Failure

E. Dupont, Tsutomu Matsushita, Riyaz A. Kaba et al. · Journal of Molecular and Cellular Cardiology · 2001 · 313 citations

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