Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

Sandra Strautnieks, Laura N. Bull, Alexander S. Knisely et al. · Nature Genetics · 1998 · 999 citations

Medicine, Genetics, Molecular Genetics +13

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

Bruno Stieger, Karin Fattinger, Jerzy Madon et al. · Gastroenterology · 2000 · 583 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions

Karin Fattinger · Clinical Pharmacology & Therapeutics · 2001 · 505 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors

Jane A. Byrne, Sandra Strautnieks, Giorgina Mieli‐Vergani et al. · Gastroenterology · 2002 · 334 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

Ryan E. Morgan, Michael Trauner, Carlo J. van Staden et al. · Toxicological Sciences · 2010 · 330 citations · Full text

Medicine, Pharmacology, Toxicology +17