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Muscle Creatine: <i>In Vivo</i> Depletion by Feeding β-Guanidinopropionic Acid
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1973
Year
NutritionMuscle FunctionMuscle CreatineCaloric RestrictionAbnormal Creatine MetabolismMetabolic SyndromeMuscle PhysiologySkeletal MuscleBiochemical NutritionMetabolic SignalingHuman MetabolismMineral MetabolismHealth SciencesAnimal PhysiologyNutrient PhysiologyNeuromuscular PhysiologyPharmacologyCreatine EntryEnergy MetabolismPhysiologyExercise PhysiologySynthetic Creatine AnalogueMetabolismMedicine
The purpose of this work was to determine the in vivo effect of β-guanidinopropionic acid (β-GPA) on the metabolism of creatine. Diets containing the synthetic creatine analogue, β-GPA, were fed to pregnant female and young male rats.All rats receiving diets containing β-GPA developed the following signs of abnormal creatine metabolism: reduced muscle levels of creatine, reduced urinary excretion of creatinine, and an increase in urinary excretion of creatine.Twelve hours after an injection of creatine-1- 14 C, rats fed β-GPA had a lower radioactivity level (c.p.m.) in muscle but a higher level in urine than did rats fed the same diet without β-GPA.It is proposed that abnormal creatine metabolism results from an inhibition of creatine entry into muscle from plasma by β-GPA.