Concepedia

Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy

Luciana Schultz, Roula Albadine, Jessica Hicks, Sana Jadallah, Angelo M. De Marzo, Ying‐Bei Chen, Matthew E. Neilsen, Mark L. Gonzalgo, David Sidransky, Mark Schoenberg,

Cancer · 2010 · 74 citations · 36 references

DOI

Abstract

We found an overall down-regulation of mTOR pathway in bladder urothelial carcinoma. phosS6 independently predicted DSS, and c-myc independently predicted progression.

References

36

Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients

John P. Stein, Gary Lieskovsky, Susan Groshen et al. · Journal of Clinical Oncology · 2001 · 3.5K citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

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Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

Brett S. Carver, Jennifer Tran, Anuradha Gopalan et al. · Nature Genetics · 2009 · 658 citations · Full text

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mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms

Rajesh Kannangai, Onikepe Adegbola, Jianzhou Wang et al. · Clinical Cancer Research · 2004 · 378 citations · Full text

Prognostic relevance of the mTOR pathway in renal cell carcinoma

Allan J. Pantuck, David B. Seligson, Tobias Klatte et al. · Cancer · 2007 · 344 citations