Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

Christian Weyer, Clifton Bogardus, David M. Mott et al. · Journal of Clinical Investigation · 1999 · 2K citations · Full text

Medicine, Endocrinology, Physiology +11

TXNIP Regulates Peripheral Glucose Metabolism in Humans

Hemang Parikh, Emma Carlsson, William A. Chutkow et al. · PLoS Medicine · 2007 · 497 citations · Full text

Life Sciences, Endocrinology, Physiology +16

Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes

Jenny E. Gunton, Rohit Kulkarni, Sun-Hee Yim et al. · Cell · 2005 · 494 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +16

Thioredoxin-Interacting Protein Is Stimulated by Glucose through a Carbohydrate Response Element and Induces β-Cell Apoptosis

Alexandra H. Minn, Christian Hafele, Anath Shalev · Endocrinology · 2005 · 371 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Hyperglycemia Promotes Oxidative Stress through Inhibition of Thioredoxin Function by Thioredoxin-interacting Protein

P. Christian Schulze, Jun Yoshioka, Tomosaburo Takahashi et al. · Journal of Biological Chemistry · 2004 · 366 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17