Oligomycin E, a new antitumor antibiotic produced by Streptomyces sp. MCI-2225.

Abstract

A new oligomycin, oligomycin E (1), and known oligomycins A (2)D and B (3)2), were obtained from the culture broth of Streptomyces sp. MCI-2225 as cytotoxic compounds against HeLa cells (a uterine carcinoma cell). This paper reports the fermentation, isolation and structure of oligomycin E (1). Since no report has been made on cytotoxicity of oligomycins [A (2), B (3), C (4)1}, D (rutamycin)