Study of HL‐A Genotypes in a Case of Familial Chronic Lymphocytic Leukaemia (CLL)

Abstract

Blood groups and HL‐A antigens were determined in 12 members of a family in which chronic lymphocytic leukaemia (CLL) occurs in four siblings. The same HL‐A haplotype [Da25 (W30 + W31), HL‐A13] was observed in the three diseased siblings tested. This case, together with that of a similar family studied by Schweitzer et al. (1973), in which three out of five diseased siblings shared two antigens ‐ HL‐A2 and W5 ‐ suggests a possible linkage between HL‐A and susceptibility to CLL.