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Antitumor Agents From Bohemic Acid Complex, III. The Isolation of Marcellomycin, Musettamycin, Rudolphomycin, Mimimycin, Collinemycin, Alcindoromycin, and Bohemamine
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1980
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Medicinal ChemistryAntimicrobial Drug DiscoveryBiochemistryBioassay-guided IsolationAntitumor AgentsMedicineNatural SciencesAntimicrobial ChemotherapyAntimicrobial CompoundAntimicrobial AgentsBohemic Acid ComplexAnthracycline Antitumor AgentsPharmacologyAnti-cancer AgentPharmaceutical ChemistryDrug DiscoveryClassical Column ChromatographyDrug Analysis
Six anthracycline antitumor agents, marcellomycin, musettamycin, rudolphomycin, alcindoromycin, collinemycin, and mimimycin, have now been isolated from bohemic acid complex. This has been achieved by classical column chromatography with Sephadex LH-20 and ammonia-neutralized silica and by analytical and prepatative hplc techniques with normal phase systems containing aqueous ammonia.