Science · 1971 · 98 citations · 11 references
MedicineHematologyImmunologyClinical ImmunologyHemostasisImmunopathologyCoagulation AbnormalitiesCoagulation DisordersHemolytic DisordersHemostasis DisordersHemostatic DisordersVon Willebrand DiseaseAssayFactor Viii ActivationHemagglutination AssaysHemagglutination Inhibition AssaysVon Willebrand Disease DiagnosisVon Willebrand Factor Activity AssaysVon Willebrand Factor AntigenVon Willebrand Factor Function
Factor VIII activity was detected immunologically in both the serums and plasmas of 14 normal individuals and 14 patients with hemophilia A. A hemagglutination-inhibition test with rabbit antibody to highly purified (10,000-fold) factor VIII from humans was used. Serums and plasmas from eight patients with von Willebrand's disease showed little or no factor VIII activity in this test, an indication that the test may serve as a specific assay for differentiation between von Willebrand's disease and hemophilia A.
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Two Types of Haemophilia (A<sup>+</sup> and A<sup>−</sup>): A Study of 48 Cases
K. W. E. Denson, Rosemary Biggs, M.E. Haddon et al. · British Journal of Haematology · 1969 · 119 citations
Medicine, Hematology, Immunology +11