Effects of Histamine and the H2 Receptor Antagonist Ranitidine on Ischemia-Induced Acute Renal Failure: Involvement of IL-6 and Vascular Endothelial Growth Factor

Abstract

These results indicate an important role of histamine in kidney damage following renal ischemia. The beneficial effects of ranitidine were partly mediated by decreased IL-6 and VEGF mRNA expression and significant early increase in renal VEGF abundance.