Organic Letters · 2011 · 91 citations · 90 references
Natural SciencesChemistryCatalysisChemical KineticsOrganic ChemistryCatalytic MechanismsCatalytic Reaction KineticsChemical Reaction KineticsEnzyme KineticsReaction MechanismsCatalytic Reaction MechanismsKinetic Resolution
A dual-catalysis approach enables the small-molecule catalyzed kinetic resolution of allylic amines by acylation. By employing 2 mol % of each 4-(pyrrolidino)pyridine (PPY) and a readily available chiral hydrogen-bonding cocatalyst, the first nonenzymatic kinetic resolution of allylic amines was accomplished with s factors of up to 20.
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