Bioscience Biotechnology and Biochemistry · 1996 · 25 citations · 0 references
MedicineBiochemistryPharmacologyBiological Transport PhenomenaIntracellular TransportMolecular PharmacologyEnzyme InhibitionGastrointestinal AbsorptionGastrointestinal PharmacologyIntestinal AbsorptionTransporter PharmacologyArginine-rich PeptidesCationic PeptidesIntestinal Epithelial TransportersMucosal TransportersPeptide TransportersSubstrate Binding Specificity
Arphamenine A, an Arg-Phe analog without a peptide bond, has been reported to be a possible inhibitor of the peptide transporter [H. Daniel and S.A. Adibi, FASEB J., 8, 753 (1994)]. The present study demonstrated that arphamenine A is not a real inhibitor, but is a substrate for the transporter, being transported transepithelially under a proton gradient. The substrate specificity of the peptide transporter was wider than expected.