Soot-Exposed Mononuclear Cells Increase Inflammatory Cytokine mRNA Expression and Protein Secretion in Cocultured Bronchial Epithelial Cells

Abstract

Exposure to soot particles induces an autocrine stimulation of inflammatory cytokine release by blood monocytes and BEAS-2B cells. Since IL-6 and IL-8 play a major role in the pathogenesis and persistence of bronchial inflammation, these findings may serve as a partial explanation for the aggravation of asthmatic and bronchitic symptoms after exposure to soot.