A New Bisabolene Epoxide from <i>Tussilago</i> <i>farfara</i>, and Inhibition of Nitric Oxide Synthesis in LPS-Activated Macrophages

Abstract

A new bisabolene epoxide was isolated from the flower buds of Tussilago farfara, and the structure was determined by spectroscopic methods to be 1alpha,5alpha-bisacetoxy-8-angeloyloxy-3beta, 4beta-epoxy-bisabola-7(14),10-dien-2-one (1). Compound 1 showed inhibition of nitric oxide synthesis in lipopolysaccharide-activated macrophages.