Enhanced Intracoronary Thrombolysis With Urokinase Using a Novel, Local Drug Delivery System

Abstract

Local urokinase delivery with the Dispatch catheter can result in rapid and complete intracoronary thrombolysis using substantially less drug than standard thrombolytic techniques. Intramural deposition of drug with this technique creates a local reservoir of urokinase that may provide prolonged thrombolytic activity at the infusion site.