Proteasome inhibition sensitizes non–small cell lung cancer to histone deacetylase inhibitor–induced apoptosis through the generation of reactive oxygen species

Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer

Joan H. Schiller, David Harrington, Chandra P. Belani et al. · New England Journal of Medicine · 2002 · 4.9K citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

Frank J. T. Staal, Mario Roederer, L A Herzenberg et al. · Proceedings of the National Academy of Sciences · 1990 · 959 citations · Full text

Immunology, Immune Regulation, Intracellular Thiol Levels +19

Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.

Wm. Kevin Kelly, Victoria M. Richon, Owen A. O’Connor et al. · PubMed · 2003 · 623 citations

Acetylation of the C Terminus of Ku70 by CBP and PCAF Controls Bax-Mediated Apoptosis

Haim Cohen, Siva Lavu, Kevin J. Bitterman et al. · Molecular Cell · 2004 · 574 citations · Full text

Signal Transduction, Signaling Pathway, Apoptosis +7

Histone deacetylase (HDAC) inhibitor activation of p21 ^WAF1 involves changes in promoter-associated proteins, including HDAC1

C. Gui, Lang Ngo, Weili Xu et al. · Proceedings of the National Academy of Sciences · 2004 · 549 citations · Full text

Histone Modifications, Epigenetic Change, Genetics +25