Asymmetric Organocatalytic N‐Alkylation of Indole‐2‐carbaldehydes with α,β‐Unsaturated Aldehydes: One‐Pot Synthesis of Chiral Pyrrolo[1,2‐<i>a</i>]indole‐2‐carbaldehydes

Abstract

Like water from a duck's back: A highly enantioselective organocatalytic cascade aza-Michael/aldol reaction of indole-2-carbaldehydes with α,β-unsaturated aldehydes has been developed, providing an easy access to pyrrolo[1,2-a]indole-2-carbaldehydes with moderate to excellent enantioselectivities in one single reaction (see scheme).