Effect of Chlorothiazide Therapy on Serum Uric Acid and Uric Acid Excretion

Abstract

DURING preliminary testing in 1957, chlorothiazide revealed its effectiveness as a diuretic for oral administration.1 It was observed some months later also to have an antihypertensive effect.2 The present study was undertaken because of the relation between chlorothiazide and salicylate as inhibitors of uric acid secretion first suggested by Yü and Gutman.3 Material and MethodsTen patients who had been receiving chlorothiazide up to ten months were asked to return to the hospital. During the first forty-eight-hour admission, they had two determinations each of blood urea nitrogen, serum uric acid (by Caraway's4 method) and electrolytes, and collected all urine in . . .