Novel [3+2] Cycloaddition of Alkylidenecyclopropanes with Aldehydes Catalyzed by Palladium

Abstract

Multiply substituted tetrahydrofuran rings can be prepared by the [3+2] cycloaddition of alkylidenecyclopropanes 1 with aldehydes 2 [Eq. (1)]. In this reaction, the distal bond of the cyclopropane ring is cleaved, and 3-methylenetetrahydrofuran derivatives 3 are produced in good yields.