Concepedia

Direct Assembly of Aldehydes, Amino Esters, and Anilines into Chiral Imidazolidines via Brønsted Acid Catalyzed Asymmetric 1,3-Dipolar Cycloadditions

Weijun Liu, Xiaohua Chen, Liu‐Zhu Gong

Organic Letters · 2008 · 101 citations · 46 references

DOI

Concepts

Abstract

A chiral Brønsted acid catalyzed 1,3-dipolar cycloaddition reaction directly assembles aldehydes, amino esters, and anilines into synthetically useful chiral imidazolidines with high levels of stereoselectivity (up to 91/9 dr and 98% ee).

References

46

Enantioselective Mannich‐Type Reaction Catalyzed by a Chiral Brønsted Acid

Takahiko Akiyama, Junji Itoh, Koji Yokota et al. · Angewandte Chemie International Edition · 2004 · 1.6K citations · Full text

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Chiral Brønsted Acid-Catalyzed Direct Mannich Reactions via Electrophilic Activation

Daisuke Uraguchi, Masahiro Terada · Journal of the American Chemical Society · 2004 · 1.6K citations

, , +15

Chiral Counteranions in Asymmetric Transition-Metal Catalysis:  Highly Enantioselective Pd/Brønsted Acid-Catalyzed Direct α-Allylation of Aldehydes

Santanu Mukherjee, Benjamin List · Journal of the American Chemical Society · 2007 · 608 citations

, , +14

Intramolecular 1,3-dipolar cycloaddition reactions in targeted syntheses

Vijay Nair, T. D. Suja · Tetrahedron · 2007 · 433 citations

, , +2

Readily Available Biaryl P,N Ligands for Asymmetric Catalysis

Thomas F. Knöpfel, Patrick Aschwanden, Takashi Ichikawa et al. · Angewandte Chemie International Edition · 2004 · 375 citations · Full text

, , +10