International Journal of Technology Assessment in Health Care · 2003 · 12 citations · 0 references
Veterinary MedicineInfectious DiseasesPreventive MedicineCost-effectiveness AnalysisImmunizationVaccinologyCost-effectiveness ModelingImmunization CoverageVaccinationVaccine EffectivenessVaccine EfficacyViral HepatitisCost-effectivenessCost-effectiveness Of VaccinationDisability-adjusted Life ExpectancyDisability-adjusted Life Year AnalysisDisability-adjusted Life YearsImmunization Cost-effectivenessLatin Hypercube SamplingVaccination Economics
This study examines the parameters crucial to cost-effectiveness of universal hepatitis B immunization in India. An incremental cost-effectiveness analysis was done using a decision tree (Markov model) to follow up a hypothetical cohort of 100,000 newborns for the effects of hepatitis B acquired vertically at birth. The measure of effectiveness was disability-adjusted life-years gained. Uncertainty analysis and Scenario analysis were done using Latin hypercube sampling. Hepatitis B endemicity is the most important factor, followed by the cost of vaccine. Other factors of some influence are vaccination coverage, vaccine efficacy, HBeAg positivity, and vaccine wastage.