Inotropic Support During Experimental Endotoxemic Shock: Part I. The Effects of Levosimendan on Splanchnic Perfusion

Abstract

Levosimendan administered after the establishment of endotoxemic shock to pigs receiving moderate fluid resuscitation prevented further increases in MPAP and maintained a low SVR. There were, however, no improvements in CO, MAP decreased, and levosimendan neither prevented the development of circulatory shock nor improved hepatosplanchnic perfusion.