The Three‐Component Reaction between Isatin, α‐Amino Acids, and Dipolarophiles

Abstract

Abstract 3‐Spiro[pyrrolidino‐oxindoles] were prepared in high yields from a three‐component reaction between isatin, an α‐amino acid, and a dipolarophile. Both N ‐substituted and N ‐unsubstituted α‐amino acids were used as the amine component. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)