Variant alleles of the Wnt antagonist <i>FRZB</i> are determinants of hip shape and modify the relationship between hip shape and osteoarthritis

Abstract

The rs288326 and rs7775 FRZB SNPs are associated with the shape of the proximal femur. The presence of the rs288326 SNP alters the relationship between proximal femur shape and incident radiographic hip OA. These findings suggest that FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.