Highly selective toxic and proapoptotic effects of two dimeric ribonucleases on thyroid cancer cells compared to the effects of doxorubicin

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

Mitophagy, Signal Transduction, Mitochondrial Function +8

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

Edna Teruko Kimura, Marina N. Nikiforova, Zhaowen Zhu et al. · PubMed · 2003 · 1.5K citations

Tumor Biology, Somatic Mutation, Somatic Variant +15

Culture of hormone-dependent functional epithelial cells from rat thyroids.

Francesco Saverio Ambesi‐Impiombato, L. A. Parks, H G Coon · Proceedings of the National Academy of Sciences · 1980 · 958 citations · Full text

Animal Physiology, Rat Thyroids, Rat Thyroid +14

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

Michèle Grieco, Massimo Santoro, Maria Teresa Berlingieri et al. · Cell · 1990 · 957 citations

Oncogenic Agent, Thyroid Disease, Pathology +7

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

British Journal of Cancer · 1998 · 654 citations · Full text

Experimental Neoplasia, Animal Testing, Second Edition +10