Increased Cell Membrane Permeability in the Pathogenesis of Hereditary Spherocytosis *

Abstract

1 Normal human serum albumin was obtained from Massachusetts Public Health Biologic Laboratories as a 25% solution. After dialysis against appropriate buffer the solution was diluted to a final concentration of 5% in buffer. Previous studies (26, 27), especially evidence recently presented (28), indicate that plasma when in- cubated undergoes alterations in its lipid moieties that