Organic Letters · 2012 · 258 citations · 37 references
Natural SciencesChemistryCatalysisOrganic ChemistryOrganometallic ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsOrganic SynthesisOrganometallic SynthesisC-h Bond ActivationIsoquinoline ChemistryIsoquinoline SynthesisMetal-carbon Bond ActivationRuthenium-catalyzed Coupling
Aromatic and heteroaromatic ketoximes underwent cyclization with alkynes in the presence of a catalytic amount of [{RuCl(2)(p-cymene)}(2)] and NaOAc to give isoquinoline derivatives in good to excellent yields in a highly regioselective manner.
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