The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.1K citations · Full text

Dna, Engineering, Dna Analysis +20

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.1K citations

Engineering, Dna Analysis, Molecular Biology +19

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

Michael A. Frohman, Michael Dush, Gail R. Martin · Proceedings of the National Academy of Sciences · 1988 · 4.6K citations · Full text

Variant Mrnas, Genetics, Molecular Biology +17

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

Kary B. Mullis, Fred Faloona, S. Scharf et al. · Cold Spring Harbor Symposia on Quantitative Biology · 1986 · 3.5K citations

Genetics, Dna Analysis, Molecular Biology +20

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

A Ullrich, Lisa M. Coussens, Joel S. Hayflick et al. · Nature · 1984 · 2.8K citations

Tumor Biology, Carcinoma Cells, Medicine +9