Effects of Steroidal and Non-Steroidal Anti-Inflammatory Agents on Corneal Wound Healing

Abstract

This study was designed to compare corticosteroids with ketorolac, a non steroidal anti-inflammatory drug on corneal wound healing in rabbits. The present studies indicate that 0.5% ketorolac does not significantly impair wound healing as determined by corneal tensile strength, whereas 0.1% solution of dexamethasane phosphate resulted in a significant impairment of wound healing. In addition, ketorolac does not impair healing of corneal epithelial abrasion, whereas prednisolone acetate was found to impair wound healing. The development of a non-steroidal anti-inflammatory drug such as ketorolac provides an alternative method to suppress post-surgical inflammation and does not adversely affect the cellular system involved in corneal repair.