Publication | Closed Access
In vitro and in vivo Drug Studies with Three Agents of Central Nervous System Phaeohyphomycosis
85
Citations
0
References
1987
Year
Antiparasitic AgentVitro SusceptibilityMedicinal FungiDermatologyExperimental PharmacologyDrug ResistanceAmphotericin BAntimicrobial ResistanceParasitologyAmph BHealth SciencesAntifungal AgentsNeuropharmacologyNervous SystemPharmacologyFungal PathogenVivo Drug StudiesAntifungal AgentPhysiologyCentral Nervous SystemMedicineDrug DiscoveryThree Agents
Amphotericin B (Amph B), 5-fluorocytosine (5-FC), ketoconazole (KTZ), fluconazole (FLZ), amorolfine (AMOR) and terbinafine (TER) were tested against 3 agents of central nervous system phaeohyphomycosis in vitro and in life-threatening infections in mice. The fungi studied were Cladosporium bantianum, Dactylaria constricta and Wangiella dermatitidis. The broadest protection against this group of fungi in mice was offered by 5-FC followed by Amph B and FLZ, then KTZ. AMOR and TER were inactive in vivo. The results of in vitro susceptibility testing had no predictive value. In contrast, the data obtained from the mouse models should be useful clinically.