Angewandte Chemie International Edition · 2003 · 61 citations · 39 references
Natural SciencesChemistryMedicinal ChemistryNatural Product BiosynthesisOrganic ChemistrySynthetic Medicinal ChemistryEnzyme InhibitionHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisRetrosynthetic AnalysisMedicinal HeterocyclesNatural Product Total SynthesisSqualene SynthaseTotal Synthesis-derived Analogues
Ketal isomers avoided. The unique 2,8-dioxabicyclo[3.2.1]octane core of zaragozic acid C (1) was constructed in a Rh-catalyzed 1,3-dipolar cycloaddition of an alkyne to an ester carbonyl ylide. Another feature of this improved synthesis is the construction of the alkyl side chain at C1 by olefin cross-metathesis.
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Paul R. Blakemore, W.J. Cole, Philip Kocieński et al. · Synlett · 1998 · 698 citations
New Approaches to Olefin Cross-Metathesis
Helen E. Blackwell, Daniel J. O’Leary, Arnab Chatterjee et al. · Journal of the American Chemical Society · 1999 · 358 citations
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.
D. L. Pompliano, S.D. Mosser, Elaine Rands et al. · Journal of Biological Chemistry · 1993 · 258 citations · Full text
Medicine, Cancer Biology, Oncology +12