Concepedia

Anesthetic Preconditioning Enhances Ca2+Handling and Mechanical and Metabolic Function Elicited by Na+–Ca2+Exchange Inhibition in Isolated Hearts

Jianzhong An, Samhita S. Rhodes, Ming Tao Jiang, Zeljko J. Bosnjak, Ming Tian, David F. Stowe

Anesthesiology · 2006 · 22 citations · 16 references

DOIFull text

Open access

Abstract

APC plus Na+-Ca2+ exchange inhibition exerts additive protection in part by reducing systolic and diastolic Ca2+ overload, respectively, during ischemia-reperfusion. Less degradation of sarcoplasmic reticular Ca2+-cycling proteins may also contribute to cardiac protection.

References

16

A Novel Isothiourea Derivative Selectively Inhibits the Reverse Mode of Na+/Ca2+ Exchange in Cells Expressing NCX1

Takahiro Iwamoto, Tomokazu Watano, Munekazu Shigekawa · Journal of Biological Chemistry · 1996 · 505 citations · Full text

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Anesthetic-induced Preconditioning 

Brian A. Cason, A. K. Gamperl, Robert H. Slocum et al. · Anesthesiology · 1997 · 233 citations · Full text

Cardiac-Specific Ablation of the Na <sup>+</sup> -Ca <sup>2+</sup> Exchanger Confers Protection Against Ischemia/Reperfusion Injury

Kenichi Imahashi, Christian Pott, Joshua I. Goldhaber et al. · Circulation Research · 2005 · 163 citations

Sevoflurane Exposure Generates Superoxide but Leads to Decreased Superoxide During Ischemia and Reperfusion in Isolated Hearts

Leo G. Kevin, Enis Novalija, Matthias L. Riess et al. · Anesthesia & Analgesia · 2003 · 127 citations

Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia–reperfusion injuries

Kenzo Takahashi, Teisuke Takahashi, Taizo Suzuki et al. · European Journal of Pharmacology · 2002 · 109 citations

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